JAK2 Val617Phe activating tyrosine kinase mutation in juvenile myelomonocytic leukemia
نویسندگان
چکیده
منابع مشابه
Cytogenetic and FMS-Like Tyrosine Kinase 3 Mutation Analyses in Acute Promyelocytic Leukemia Patients
Background: The secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (PML-RARA) fusion gene may contribute to the acute promyelocytic leukemogenesis. Chromosomal alterations and mutation of FLT3 (FMS-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. However, the prognostic significance of FLT3 mutat...
متن کاملMutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia.
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK-signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.
متن کاملJuvenile myelomonocytic leukemia.
A was less than 4 years, with any type of myelodysplasia and monosomy 7. All other patients, including older children BOUT 40 YEARS ago two forms of chronic myelocytic leukemia (CML) were recognized in children. One had the typical features of CML of adulthood and usually with monosomy 7, were classified according to FAB criteria. The revised classification led the authors to propose a new appe...
متن کاملPEDIATRIC HEMATOLOGY Juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is a rare clonal myeloproliferative disorder (MPD) of early childhood [1]. The median age at diagnosis is 2 years [1]. There is a male predominance with a male:female ratio of 2:1. Pallor, fever, infection, skin bleeding and cough are the most common presenting symptoms. Typically, there is marked hepatosplenomegaly. JMML rarely involves the central nervo...
متن کاملPathogenic Mechanisms in Juvenile Myelomonocytic Leukemia
Juvenile myelomonocytic leukemia (JMML) is a relentless myeloproliferative disorder (MPD) of young children characterized by over-production of myeloid lineage cells that infiltrate hematopoietic and non-hematopoietic tissues including skin, lung, and spleen. The median survival is < 1 year without hematopoietic stem cell transplantation (HSCT). A cellular hallmark of JMML is that primary blood...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2005
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2403903